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Details of Research:
 
To assess the detoxification efficacy, these medicines were subjected to animal trials and thoroughly tested upon animals of various species for different intoxicants such as :

Alcohol:

At first, these medicines were tested for addiction of alcohol in monkeys. To begin with, experimental neurosis was developed in monkeys by subjecting them to neurotogenic trauma.They were served food; and a rubber snake was concealed in their food. While eating, they sighted the rubber snake in their food.They got agitated and refused to eat. By virtue of repetition of this process, neurosis developed in them. Then, they were given 1.5 ml/kg (body weight) alcohol. This dose of alcohol disintegrated the neurotic complex. Neurotic monkeys, when mildly intoxicated, resumed eating. After experiencing relief from neurotic tension, they preferred taking some alcohol before meals; otherwise, they were unable to take food. Hence, addiction to alcohol developed in them.

These monkeys were divided into two groups. One group was given Detoxin and the other group was given Placebo with following results:

Group treated with
No. of monkeys treated
No. of monkeys resumed eating without alcohol
No. of monkeys resumed eating but less without alcohol
No. of monkeys did not resume
eating
Detoxin
10
8
1
1
Placebo
10
Nil
1
9


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Morphine: Acute dependence

This experiment was conducted upon Albino mice. Samples of 60 Albino mice were taken and were given Morphine HCL 20 mg/kg (body weight). About 4 hours later these mice were divided into two groups. One group was given Detoxin and the other one Placebo. After 5 minutes. both groups were given Nalaxone 5 mg/kg (body weight). Following results observed:

Group treated with Total no. of mice

no withdrawals found in

Rearing occurred Jumping, urination, defaecation occurred in
Detoxin 30 22 7 1
Placebo 30 3 27 27
 

Barbiturates

For this experiment, samples of 20 cats were taken. They were given Sodium Barbital 95 mg/kg (body weight) two times daily and this dose was increased gradually, until the dose level of Sodium Barbital reached to 200 mg/kg in 180 days. Then, these cats were divided into two groups and were deprived of Sodium Barbital. Thereafter, one group was given Detoxin and Placebo was given to the other group.
Following results observed:

Group treated with No. of cats Strong seizures occurred in Mild seizures occurred in seizure occurred in
Detoxin 10 - 2 8
Placebo 10 9 1 -
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Clinical Trial

192 cases of addicts of various types were studied. Directly administering Detoxin to the control group was not considered necessary as Placebo effect gets nullified while testing the potencies. Moreover, each potency of Detoxin can not suit to a person. Had there been placebo effects, each potency of Detoxin would suit. This study of 192 cases was conducted for 1 year. The Observations are as follows:

AGE :

Below 20 yrs. 21-30 yrs. 31-40 yrs. 41-50 yrs. 51-60 yrs. Above 60 yrs.
14
72
57
25
17
7

Educational Status :

Nil Primary School Junior High School High School Intermediate
39 17 25 32 29
Graduate Post Graduate Professionals Misc.
23 9 13 5

Profession :

Unemployed

Govt. Service Advocate Farmer Driver Hotel Business
26 18 4 34 16 2 21
Pvt. Service

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Student Technical Laborer Misc.
9 5 15 4 4 34

 

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Marital Status :

Unmarried Married Widower Divorcee Separated
22 91 10 27 42

Addiction :

Alcohol Cannabis Opiates Alcohol, Cannabis Alcohol, Opiates
69 13 58 15 9
Alcohol, Diazepam, Opiates Alcohol, Cannabis, Opiates Opiates, Diazepam Cannabis, Opiates
3 9 1 15

 

Relapse :

Alcohol Cannabis Opiates Alcohol, Cannabis Alcohol, Opiates
32 4 26 3 3
Alcohol, Diazepam, Opiates Alcohol, Cannabis, Opiates Opiates, Diazepam Cannabis, Opiates
1 2 1 6

 

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Relapsed During :

0-3 months 3-6 months 6-9 months After 9 months
35 21 12 10

Relapsed Due to :

Withdrawal Craving Impotency Family Tension Company Drug Peddling
3 4 31 14 9 17

 

Another separate study was also conducted in which cases of smoking/chewing tobacco were studied; though, some of them used to take occasionally other intoxicants or were addicted to them such as alcohol, cannabis, sedatives, Hypnotics and antidepressent. Details are as follows :

Addiction :

Chewing Tobacco Smoking Both
95 531 41

Relapse :

Chewing Tobacco Smoking Both
19 117 8

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Relapsed During :

1st week 2-4 week 2-3 months 3-6 months 6-9 months After 9 months
23 36 21 26 23 15

Relapsed Due to :

Did not take medicine properly Urge With-drawl Persuasion by someone curiosity
19 13 5 8 32
Mental shock no reason Loneliness Desire to hold some- thing between fingers ignorance of the medical instructions
12 27 4 6 18

 

When they smoked again, they experienced :

Aversion Usual taste Mild taste /tastelessness
63 37 44

The persons who got relapsed, started to take quantity/day :

Reduced Same increased
88 43 13

 

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